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@FoundMyFitnessمنذ 4 سنوات - Intro.
- Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells.
- Overview of NAD+
- NAD+ plays an important role in mitigating DNA damage.
- Excessive DNA damage can decrease NAD+ levels by 20-30%.
- Lymphoblastoid cells from centenarians show increased PARP-1 activity.
- Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan.
- Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan.
- NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes.
- Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio.
- NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age.
- Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal.
- NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents.
- In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide.
- Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy.
- Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity.
- Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory.
- A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice.
- NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice.
- Plausibility of dosing: comparing animal and human doses.
- Tissue-specific metabolism and bioavailability of NR and NMN.
- Oral administration of NAD produces NR and NMN in the intestine.
- Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain.
- Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health).
- Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%.
- Concluding thoughts and recap. ....وسعت 286
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@bahb00منذ 4 سنوات Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 247
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@Spicydoc1منذ 2 سنوات How Lucky we are to have Dr. Patrick in our lives. She is amazing. Knowledge just oozes out of her.. 16
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@pablopolski1228منذ 4 سنوات Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 395
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@scott.joshuaمنذ 4 سنوات What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 28
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@keng7758منذ 2 سنوات I simply love your style of presenting with the latest facts. You speak fast, which I like! The data you provide and the research you do prior to presenting id="hidden3" class="buttons"> makes you one of the best health span advocates on YouTube. Thank you Rhonda! ♥️ ....وسعت 5
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@chrisbenton5335منذ 4 سنوات Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 123
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@nolimit1152منذ 4 سنوات A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 9
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@DDFaye74منذ 3 سنوات This is just about the most thorough and intelligent PP presentation I've ever seen. She is one smart lady! Wow.
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@roblovegreenمنذ 4 سنوات Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 61
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@turinhorseمنذ 4 سنوات few notifications on youtube get me as excited as a video from Dr. Rhonda Patrick. 3
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@richrozmarn3817منذ 4 سنوات Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 56
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@optimizewithscience8883منذ 4 سنوات It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 40
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@davidevans1420منذ 4 سنوات Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health. ....وسعت 24
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@mvrao29العام الماضي It appears that Dr Rhonda does a lot of preparation and compilation of subject matter for making each video. Her tone and presentation skills are excellent. id="hidden8" class="buttons"> She seems to be interested in sharing her in depth knowledge for the good of the people. God Bless Dr Rhonda Patrick ....وسعت 1
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@Noveleffectمنذ 4 سنوات I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 5
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@juneallison7052منذ 3 سنوات Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤ 2
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@tonywestbrook9876منذ 4 سنوات I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 29
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@Healitnowمنذ 4 سنوات Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going id="hidden10" class="buttons"> out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺ ....وسعت 5
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@gururajbsavakar7154منذ 4 سنوات Congratulations!
Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters id="hidden11" class="buttons"> of NAD, & Alternate pathways which work usually but with exceptions!!!
Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities .
With a final recap!!
Thanks for this useful educative share! Many regards! ....وسعت 5
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@18KarlaGمنذ 4 سنوات 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2
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@wolframluchner5316منذ 4 سنوات Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7
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@rickm6807منذ 3 سنوات Holy crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you!!! 1
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@ALulzyApprenticeمنذ 2 سنوات This is the most comprehensive video I have seen on this topic. You are a gem. Thank you.
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@heroicalx786منذ 4 سنوات Dr. Rhonda, the people's champion! 46
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@TheEatraumمنذ 4 سنوات Damn. I need an IV of this channel straight into my brain. Oh, and that other stuff you were talking about, as well. 121
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@tomjones2348منذ 4 سنوات I like to watch informational videos like this while doing my hour of piano warm ups. Nope.can't do it on this one. Need to give this video my 100% attention. Thanks Dr. Patrick. 1
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@cuentadeyoutube5903منذ 4 سنوات Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3
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@ngallureمنذ 4 سنوات So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless id="hidden14" class="buttons"> way you explain potentially mind boggling processes. Helps so much in the decision making process. ....وسعت 1
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@Libertas_P77منذ 4 سنوات Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 3
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@profitfeverمنذ 4 سنوات So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8
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@mookywilson1054منذ 4 سنوات DOC!!!! your the best! I wish there were more docs like you. 4
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@JosetteBadgerمنذ 2 سنوات You remind me of my favorite med school professor- one of my favorite instructors of all time
Thanks for the clear and concise video!
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@tomprovan6817منذ 4 سنوات This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video
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@johnhunt3759منذ 4 سنوات Thank you . Please do not stop helping people the way you do. 1
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@tominatrمنذ 3 سنوات I could look and listen to her all day.
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@echomanechoman78منذ 4 سنوات The best all-in-one-video on Youtube that explains NAD+
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@squamish4244منذ 4 سنوات NAD+ is a miracle drug and no mistake. The hype is real. It has had a profound effect on my mental and physical health at the age of 41, after many years id="hidden16" class="buttons"> of drug abuse, persistent old injuries, and the general exhaustion brought on by 25 years of OCD and sky-high anxiety. ....وسعت 3
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@lightinthedark33منذ 2 سنوات What a great video doc.
I saw you in person once but did not want to bother (Fashion Valley). I would consider you to be one of my hero’s in the health field… I’ve been greatly inspired by you and Dr.Sinclair to understand health from a scientific basis in hopes that I can pass this knowledge onto my mother who has MS and the rest of my loved ones.
Thank you for what you do. ....وسعت
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@pravoslavnمنذ 4 سنوات Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2
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@dukecityrecordsقبل 11 أشهر Thank you Dr. Patrick I appreciate the honest review as someone who was just looking into this I really appreciate the data and information you've brought forward. Please continue to be an Amazing Doctor! ❤ 1
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@richardwheeler1387منذ 4 سنوات Best presentation on the NAD/NMN potential and current status I have seen anywhere.
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@unclejoe3397منذ 4 سنوات Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1
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@spockboyمنذ 4 سنوات Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3
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@andrewmooreoneمنذ 4 سنوات Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1
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@stephenhurst1348منذ 4 سنوات Thank you so much for the thorough long-form video, all of this information is very important. 1
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@LaunchMedicalMediaمنذ 4 سنوات This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on!
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@mr.reberdo6141منذ 4 سنوات Best video I’ve seen on the subject.
Thank you!! 4
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@DavidSchwartzjrمنذ 4 سنوات Been looking into this a bit recently. Thanks for the new upload, Rhonda! 1
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@equsnarndمنذ 4 سنوات I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11
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@CompSourceمنذ 4 سنوات Wow amazing job and the best, most concise source of information I've ever seen for NAD oh, great job! 1
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@MrJamesdryableمنذ 4 سنوات I weigh exactly 180 pounds. this is great. 42
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@kuo-yingwang2273منذ 2 سنوات Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches.
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@peterdavila3045منذ 2 سنوات I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy id="hidden22" class="buttons"> I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks.
My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol.
Live Long Enough to Live Foreever. ....وسعت 22
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@firehorse_44alpha-omega99منذ 4 سنوات Excellent lecture.
Thank you for this presentation Dr.
Cheers 10
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@realtriumphمنذ 4 سنوات Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. id="hidden23" class="buttons"> I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. ....وسعت 14
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@2kosioمنذ 4 سنوات Congratulations - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time 1
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@lucmarcoux2144منذ 4 سنوات Wow, thank you for that full explanation. I have cut sugars, am into intermittent fasting, with 4 prolong 5day fast a year, and now looking into Mr Sinclair's id="hidden24" class="buttons"> research. I don't look anywhere my age, I'm told. Exercise and eating right is crucial. I am a nut at getting my DNA and any acetylation or methylation repairs done. Doing the autophagy route for this right now. I was thinking of these surpluses, but I think, I'll stick with my diet and exercise routine. Thank again, great explanation, backed with studies. I'm loving you already! ....وسعت 1
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@noemiromero4729منذ 4 سنوات You are amazing!!! This material is so useful! 12
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@Hgulix62منذ 4 سنوات I think you can't make more concise and comprehensible than this 1
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@BD-xf7ynمنذ 3 سنوات Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level
We all need to wait for using supplement at this point till more data available! 2
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@jhumm007منذ 4 سنوات I've been taking 1g of NR daily for 2 years. I find that I don't get jet lag or hangovers anymore. My contribution to this fascinating science. 16
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@lpngolferمنذ 4 سنوات Thank you so much for giving this teaching on this topic. Valuable information! 2
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@michelleguerrero2848منذ 4 سنوات Dr. talks to us like we could really get it.I do!!! 15
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@Morroccomethodrawمنذ 4 سنوات So helpful + informative for learning about aging. Thank you for this video! 2
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@dr.stevehrubyd.c.3666منذ 4 سنوات Thank you Dr Patrick this is above and beyond anything that is out there. 1
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@billyjoehugginsمنذ 4 سنوات Thank you, Dr. Rhonda Patrick! Great information! 2
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@peterwu5091منذ 4 سنوات I'm exactly 180lb, thank you for this vid! 3
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@Roger-Bowmanمنذ 2 سنوات Stellar presentation as always, thank you Dr. Patrick!
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@jawi499منذ 4 سنوات Good work! You certainly did the research and can explain it with great accuracy. Thank you.
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@ramonmensink9458منذ 4 سنوات Great video Rhonda!
I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat.
As you also explain id="hidden27" class="buttons"> in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising.
Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it?
Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? ....وسعت 4
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@davidg.johnson7208منذ 2 سنوات Loved your interview with Dr. Daivid Sinclair! The meeting of two great doctors! Hope you have another with him! Maybe get a pre-copy of his new book to come out soon for an interview?!
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@watchutalknboutwillis1874منذ 3 سنوات its bonkers to conceive that this is free. ty Dr Patrick
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@isabellaholden8693منذ 4 سنوات Amazing video. Thank you for the brilliantly explained content. 5
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@danielthiel7913منذ 2 سنوات @Dr. Patrick - I'm curious if taking NAD+ injections is an effective substitute for NAD boosters?
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@lsporter88منذ 2 سنوات That was a very thorough explanation Dr. Patrick. Thank you.
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@robo265منذ 4 سنوات Wow talk about informative video thank you , I’ve been taking a product which contains Nicotinamide 250 mg twice a day with botanical mix alpha lipoic acid vitamin c and zinc which apparently works on the salvage pathway you have described.
The company claim that Despite all the hype surrounding the use of precursors such as NR and NMN to boost NAD+, our cells actually make nearly all of the NAD+ they need using NAM ,as you described in your presentation.
They go on to say That “as we get older, levels of the NAMPT enzyme are known to decline and the salvage pathway becomes inefficient at converting NAM into NAD+. In fact this is known to be one of the main reasons that cellular NAD+ declines as we get older. This means that if we want to make sure that NAM doesn’t build up in the cell, then we must make sure that NAMPT and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway.
I am however concerned of the effect of Nicotinamide on sirt2, they claim however that Nicotinamide does not effect sirtuins if it doesn’t hang around for a long time when the salvage pathway is working properly . I just wondered what your thoughts are on this. Again many thanks for your very detailed video ....وسعت 2
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@tahoon2009منذ 4 سنوات Awesome, best NAD video so far, you saved days of research in such information dense video, awesome work
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@catman4471منذ 4 سنوات I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg id="hidden30" class="buttons"> the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years.
I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels.
My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing.
I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off.
The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. ....وسعت 7
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@jaydon1232منذ 4 سنوات Thank you for such an educational clip . Please keep it up 3
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@clsatcمنذ 4 سنوات Dr. Rhonda - you are such an amazing speaker and i have learned so much from you. I just want to respectfully remind you that the word "associated" id="hidden31" class="buttons"> does not have the "sh" sound in it. So many people make that same mistake so probably most don't notice it. ....وسعت
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@alfredvincent13825منذ 4 سنوات Great concise presentation as always. Thank you. 2
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@claystone7729منذ 3 سنوات Thank you Rhonda I will watch this again you explain NAD+, NR and NMN excellent easy to follow. I will come back to this video on referencing one of the best out there. God Bless you.
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@lookmomitsthatboy1869منذ 4 سنوات I found out about dr ronda a few months ago! I’m 26 and haven’t became 27 yet! I owe it all to her and my broccoli sprouts
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@bneymanovمنذ 4 سنوات Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2
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@moonoom764منذ 4 سنوات Please Rhonda, the Floxing community needs you to make a video about Fluoroquinolone Toxicity! 16
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@CharlesReedPiقبل 3 أشهر Fascinating, thanks for explaining the more direct clinical results
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@astonfallen5272منذ 4 سنوات Thanx Rhonda, for an excellent presentation ! I've heard about this mainly from David Sinclair - I am following closely, and I look forward to more input from you !
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@cs-cg9wlمنذ 4 سنوات Wow, your speech is so much better. Speed, clarity, cadence, all resulting in you being much more pleasant to listen to while keeping all that detail intact. id="hidden34" class="buttons"> I remember googling you a lot after joe rogan and being a bit disappointed back then.. Time to check out Rhonda Rousey again. (althought this stuff is a bit above my head keep at it!) ....وسعت
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@simozamb7835منذ 4 سنوات THANK YOU SO MUCH!!!! I AM LOOKING FORWARD TO VIEWING OTHER VIDEOS FROM YOU!! 1
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@danno1800منذ 3 سنوات Very helpful — comprehensive — much appreciated! 2
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@DrMichaelMoellerمنذ 4 سنوات I personally get NAD IVs@ and use them with my patients and notice an increase in energy and improved cognition. 31
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@sunshinehappyfuntimesمنذ 4 سنوات Thank you for being honest and thorough. You are the best
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@vibhaspalding6457منذ 2 سنوات I have nmn and nad both in capsule form. Vitamin d, k2, quercetin, berberine, creatinine, alpha lipoic acid and some other supplements. After hip operation id="hidden36" class="buttons"> last year and sciatica, I found my recovery was a slow progress. Starting on the various supplements means faster walks with my dog. Manage strength training, aerobics very easily. Lost inches. I am atleast one size smaller than 4 months ago. Clothes are very loose. I am continuously getting complements in the gym, about how shapely I am, and someone called me best pilates bum in the class, including the pilates instructor. I have never felt this good. Reminiscent of my 30's and 40's age, when I was doing 3 hours of workout. I feel very good at 68. Thanks to Rhonda Patrick for bringing so much information to us to decide about our health. In my family, people wish to believe what the GP's say. If these doctors says, no vit d or k2, they stick by that. They do not wish to know about these supplements. Time will tell. My siblings are younger than me. ....وسعت
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@MrVeteranhawkمنذ 3 سنوات I did 10 push ups for every time she said NR or NMN, I don't have to workout until the year 2023 now..lol. But great presentation, very helpful for id="hidden37" class="buttons"> my age at 52. I've been doing a lot of research on taking supplements to increase NAD+ ....وسعت 2
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@rzomgمنذ 4 سنوات Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2
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@stephenhurst1348منذ 4 سنوات I wish these were put on the podcast app so I could listen while I drive or work.
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@devinlauwerier404منذ 4 سنوات I just hope she appreciates me keeping this comment classy.
-Thank You, Rogan again soon? 17
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@metallicamadsamمنذ 3 سنوات This is an excellent summary of the literature. Thankyou
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@transformationcentral7501منذ 2 سنوات Hi Rhonda,
Have you considered an update on your analysis of NAD boosters?
Enjoyed your take on them and certainly interested in your opinion! 2